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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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Treating these issues requires a careful B12 dosing plan

Interest in 5-Amino-1MQ centers around its role as a laboratory tool for exploring pathways associated with nicotinamide metabolism, energy balance, and metabolic regulation in controlled experimental settings

Selected Clinical Trial Activity 5-Amino-1MQ is a research-grade compound that has been studied in laboratory settings but has not undergone full clinical development