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The combination causes severe irritation without extra benefit

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In addition, oxidative stress contributes to insulin resistance in the periphery by disturbing glucose transport 4 (GLUT4), resulting in the maintenance of elevated blood glucose levels [123]

Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation

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This irritancy test approach may be extended to other similar compounds or minerals and can potentially predict the in vivo skin irritation response before conducting clinical testing on human subjects