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However, groups switched from WD to LD (WD/LD-V, WD/LD-T) tended to show greater alpha diversity compared to the control groups (WD/WD-V and LD/LD-V), which was not surprising since these animals experienced the most diet transitions with variable nutrient resources during their lifetime

Furthermore, RS may disrupt proteasomal degradation pathways, resulting in the accumulation of damaged proteins [33] ( Table 1 )

Research by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) indicates that individuals with higher tolerance are more likely to engage in hazardous drinking behaviors, potentially leading to liver damage, cardiovascular issues, and other serious health problems

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Among the key regulatory pathways, the OPG/RANKL axis and chemokine-mediated cellcell communication play pivotal roles in maintaining skeletal homeostasis