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Digestion of the sialic acid residues from the glycocalyx by neuraminidase enzyme or incubation of the cells with cationic lipid TMA-DPH made the charge of human brain endothelial cells more positive

Notably, effects were achieved via multiple routes of application including intragastric and local, suggesting broad applicability across experimental delivery methods

Because semaglutide creates a sustained appetite reduction, weight loss often persists without requiring extreme calorie restriction, making long-term metabolic improvement more achievable

Funding This study was funded by the Spanish Ministry of Economy and Competitiveness (AGL2017-89017-R and PID2021-126988OB-I00)

Diabetic retinopathy case: 54-year-old with non-proliferative diabetic retinopathy despite HbA1c 6.8%