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Multiple sequence alignment and phylogenetic assessment For each enzyme family, candidate sequences were aligned using MAFFT 91,92 ( with default parameters and visualised in the multiple sequence alignment editor AliView v1.27 93 ( To provide evolutionary context to the metazoan phylogenetic relationships, we also incorporated non-metazoan sequences

Jul-Sep 2011;53(3):153-62

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Reports indicate that when left untreated, episodes occur 4-12 times per year on average

This means the 2mg/mL concentration is not ideal for people on the highest doses unless they use a larger syringe or split the dose into two injections