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While the mechanism is not definitively established, gastrointestinal side effects may indirectly contribute to taste alterations

Forest plot of GLP-1 receptor agonists versus comparators on the risk of Bronchitis

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Combining the in vivo imaging approach with the expression of fluorescent biosensors for different variables of beta and/or alpha cell function and survival, as well as adding genetic manipulation of human islet cells using the CRISPR/cas9 system, will lead to a better understanding of human islet cell biology/pathology and specifically the role of alpha cell-derived paracrine signals for proper beta cell function and survival

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