Arkadia Polyclonal Antibody, 100ul Hepatocytes is essential for development and

is essential for development and survival of mast cells in vivo

The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions

Additional isoforms have been described for this gene but they have not yet been experimentally verified

It participates in apoptosis signaling through highly specific protein-protein homophilic interactions

Overexpression of PBK has been implicated in tumorigenesis

Arkadia Polyclonal Antibody, 100ul Hepatocytes is essential for development andThe protein encoded by RNF111 (ring finger protein 111) is a nuclear RING domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) beta NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF beta target gene transcription. As a modulator of the nodal signaling cascade, RNF111 plays a critical role in the