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Netzahualcoyotzi C, Tapia R

Sphingosine 1-phosphate (S1P) receptor modulators as an induction and maintenance therapy for ulcerative colitis: a systematic review and meta-analysis of randomized controlled trials

Use within controlled environments is recommended

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For example, in obese diabetic mice fed a methionine and choline-deficient diet (MCD), an FGF21 analog significantly reduces fibrogenic expression and inhibits hepatic fibrosis (152)

adverse or undesired effects Examples -- positive, beneficial drug interaction effects: Propranolol + hydralazine (reflex tachycardia (undesirable) caused by hypotensive hydralazine-mediated response is prevented by propranolol-mediated -adrenergic receptor blockade Opioid-induced respiratory depression may be counteracted by administration of the opioid receptor antagonist naloxone Adverse effects -- toxic reactions One drug may interact with another to impede absorption One drug may compete with another for the same plasma protein-binding sites One drug may affect metabolism of another by either enzyme induction or enzyme inhibition One drug may change the renal excretion rate of the other