Cdk9 (Acetyl Lys44) Rabbit Polyclonal Antibody, 100ul DNA Synthesis Two isoforms of MAP-9 are

Two isoforms of MAP-9 are produced due to alternative splicing events

Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product

Among its related pathways are LKB1 signaling events

which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells

The encoded protein is processed from a precursor

Cdk9 (Acetyl Lys44) Rabbit Polyclonal Antibody, 100ul DNA Synthesis Two isoforms of MAP-9 areThe protein encoded by this gene is a member of the cyclin dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2 and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK P TEFb which is an elongation factor for RNA polymerase II directed transcription and functions by phosphorylating the C terminal domain of