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This dual action is what makes it more effective than earlier GLP-1 medications for weight loss and blood sugar control, but it also means the body is adjusting to a more significant hormonal intervention

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They then come into close proximity with mitochondrial membranes, which they also penetrate and disrupt

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This clash often produces severe nausea, vomiting, and abdominal discomfortside effects already common in the first 4-8 weeks of GLP-1 therapy

When their respective postprandial concentrations were increased through exogenous infusion, GLP-1 elicited a more robust insulin response, suggesting its superior potency compared to GIP as an incretin (55)