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Severe Se deficiency may impair the thyroids ability to produce or convert thyroid hormones, potentially exacerbating hypothyroidism symptoms, such as fatigue, weight gain, and cold intolerance [88]

The treatment attenuated VPA-induced behavioral abnormalities in both Y-maze and social play tests, while also restoring prefrontal SOD and GSH-Px activity and normalizing VPA-related changes in neuronal number and soma size (Margedari et al., 2024)

Hirose L, Nosaka K, Newton M, et al

Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-1

Future direction The evolution of GLP-1RAs is increasingly shifting toward oral formulations, aiming to enhance patient adherence by eliminating the need for injections and addressing the logistical complexities associated with traditional peptide therapies [72, 73]

Give during or after mealtime