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Cardiometabolic risk factors included a mean systolic blood pressure of 128.4 mmHg, a mean total cholesterol level of 186.0 mg/dL, a mean HDL-cholesterol level of 50.9 mg/dL, and a mean triglyceride level of 128.2 mg/dL

Research involving twin studies has shown that gut microbiota composition significantly affects energy harvest and metabolic function, suggesting that probiotic modulation could influence weight regulation

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GLP-1 therapies reduced inflammatory markers and protected kidney function in animals and humans, including in the FLOW trial

Our findings reveal an early separation in the treatment effect of semaglutide that occurs even without a significant amount of weight lost and prior to full semaglutide titration, said Dr Plutzky