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Supporting this, in a phase 2a trial in people with MASLD, the dual GLP-1/GCG agonist efinopegdutide (10 mg) reduced liver fat by 72.7%, compared to 42.3% with semaglutide (1 mg) despite similar WLindicating potential weight-independent effects of GCG on hepatic steatosis [40]

Hepatology 71:722732 Polishchuk EV, Merolla A, Lichtmannegger J, Romano A, Indrieri A, Ilyechova EY et al (2019) Activation of Autophagy, observed in liver tissues from patients with Wilson disease and from ATP7B-Deficient Animals, protects hepatocytes from Copper-Induced apoptosis

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