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Maintaining 30-50 grams of healthy fats daily prevents bile sludge formation during rapid weight loss

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Notably, TGF- is considered the master regulator of fibrosis, and its downstream signalling is transduced primarily through the phosphorylation and activation of receptor-associated Smads (R-Smads), Smad2 and Smad3

As long as it dissolves into a clear solution upon reconstitution, its integrity is not compromised

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This pathway is frequently hijacked in CRC, serving as a major protective mechanism against the cytotoxicity of ROS-inducing chemotherapeutic agents such as 5-FU and oxaliplatin